教育经历

2002.09-2007.07，8040威尼斯环境学院，理学博士（环境地理学）

2003.09-2003.12，日本国土环境株式会社，访问学生

2002.07-2002.09，日本琦玉县环境科学国际中心，访问学生

1998.09-2002.07，8040威尼斯城市与环境学系，理学学士（环境学）

工作经历

2011.01至今，8040威尼斯，研究员

2009.01-2010.12，Toxicology Centre，University of Saskatchewan，Research Associate/Lab Manager

2007.09-2008.12，Toxicology Centre，University of Saskatchewan，Postdoctoral fellow

博士生导师/方向

环境化学、环境毒理学

本科生课程：环境监测与实验

学生培养

博士生

2012级：王蓓丽

2013级：李桐

2014级：高世雄

2015级：郑国贸

2016级：刘航

2017级：崔洪洋

2018级：刘鎏

2019级：孙轶斌

硕士生

2012级：郑国贸（转博）

2013级：黎敏丹

2014级：李文娟

2015级：范森荣

2017级：田天琪

2018级：文家豪

2019级：周雨岚

本科生
2010级：郑音楠、高世雄
2011级：张禾、帕合丽娅

2012级：龚灏宁

2014级：文家豪

2015级：孙轶斌

2016级：郑乐怡、黄晓红

研究项目

1) 国家自然科学基金面上项目：环烷酸类物质的污染特征及其有害成分解析（批准号：21177003，主持，2012-2015）

2) 国家科技部"863"项目：生活垃圾焚烧厂排放污染物削减与风险评价技术研究——生活垃圾焚烧厂排放污染物健康评价技术与工具研究（批准号：2012AA062802，参加，2012-2014）

3) 环保部公益性项目：极高持久性和生物蓄积性化学品筛查方法和清单研究（批准号：201309027，主持，2013-2015）

4) 国家自然科学基金重点项目：富营养化水体中新型内分泌干扰物质的污染特征和复合生态毒理效应（批准号：41330637，参加，2014-2018）

5) 国家自然科学基金优秀青年项目：污染生态化学（批准号：21422701，主持，2015-2017）

6) 国家科技部"973"青年科学家项目：富营养化湖泊中POPs在底栖-浮游耦合食物网中的传递行为和机制（批准号：2015CB458900，参加，2015-2019）

7) 国家自然科学基金面上项目：干扰生物小分子代谢污染物的非靶向分析方法学研究（批准号：201677003，主持，2017-2020）

8) 国家科技部政府间国际科技创新合作项目：保障饮用水安全的高通量毒性物质甄别技术（批准号：S2016G6417，参加，2017-2019）

9) 国家自然科学基金创新群体项目：区域环境污染的生态健康风险（批准号：41821005，参加，2019-2024）

国际期刊论文

67) Shixiong Gao, Hang Liu, Hong Chang, Zhaobin Zhang, Jianying Hu,Shu Tao, Yi Wan*. Visualized Metabolic Disorder and its Chemical Inducer in Wild Crucian Carp from Taihu Lake, China. Environmental Science & Technology, 2020, 54, 3342-3352.

66) Zhaomin Dong, Tong Li, Yi Wan*, Yibin Sun, Jianying Hu. Physiologically Based Pharmacokinetic Modeling for Chlorinated Paraffins in Rat and Human: Importance of Biliary Excretion. Environmental Science & Technology, 2020, 54, 938-946.

65) Gao S.X., Wan Y.*, Li W.J., Huang C. Visualized Networking of Co-regulated Lipids in Human Blood Based on High-Throughput Screening Data: Implications for Exposure Assessment. Environmental Science & Technology, 2019, 53, 2862-2872.

64) Wang B.L., Cui H.Y., Liu H., Wan Y.* Derivatization for Nontargeted Screening of Acids in Oilfield Refinery Wastewater: Identification and Behaviors of Recalcitrant Chlorinated Naphthenic Acids. Environmental Science & Technology, 2019, 53, 1022-1030.

63) Zheng G.M., Wan Y.*, Shi S.N., Zhao H.Q., Gao S.X, Zhang S.Y., An L.H., Zhang Z.B. Trophodynamics of emerging brominated flame retardants in the aqutic food web of Lake Taihu: Relationship with organism metabolism across trophic levels. Environmental Science & Technology, 2018, 52, 4632-4640.

62) Li T., Gao S.X., Ben Y.J., Zhang H., Kang Q.Y. Wan Y.* Screening of chlorinated paraffins and unsaturated analogues in commercial mixtures: Confirmation of their occurrences in the atmosphere. Environmental Science & Technology, 2018, 52, 1862-1870.

61) Fan S.R., Liu H., Zheng G.M., Wang Y.L., Wang S.R., Liu Y., Liu X.Q., Wan Y.* Differences in phytoaccumulation of organic pollutants in freshwater submerged and emergent plants. Environmental Pollution, 2018, 241, 247-253.

60) Zheng G.M., Wan Y.*, Shi S.N., Zhao H.Q., Gao S.X, Zhang S.Y., An L.H., Zhang Z.B. Trophodynamics of emerging brominated flame retardants in the aqutic food web of Lake Taihu: Relationship with organism metabolism across trophic levels. Environmental Science & Technology, 2018, in press.

59) Li T., Gao S.X., Ben Y.J., Zhang H., Kang Q.Y. Wan Y.* Screening of chlorinated paraffins and unsaturated analogues in commercial mixtures: Confirmation of their occurrences in the atmosphere. Environmental Science & Technology, 2018, 52, 1862-1870.
58) Fan S.R., Wang B.L., Liu H., Gao S.X., Li T., Wang S.R., Liu Y., Liu X.Q., Wan Y.* Trophodynamics of organic pollutants in pelagic and benthic food webs of Lake Dianchi: Importance of ingested sediments as uptake route. Environmental Science & Technology, 2017, 51, 14135-14143.

57) Ashrap P.#, Zheng G.M.#, Wan Y.*, Li T., Hu W.X., Li W.J., Zhang H., Zhang Z.B., Hu J.Y.* Discovery of a widespread metabolic pathway within and among phenolic xenobiotics. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (23), 6062-6067, #contributed equally.

56) Li T., Wan Y.*, Gao S.X., Hu J.Y. High-Througput determination and characterization of short-, medium, and long-chain chlorinated paraffins in human blood. Environmental Science & Technology, 2017, 51, 3346-3354.

55) Li T., Wan Y.*, Ben Y.J., Fan S.R., Hu J.Y. Relative importance of different exposure routes of heavy metals for humans living near a municipal solid waste incinerator. Environmental Pollution, 2017, 226, 385-393.

54) Ben Y.J., Li T., Wan Y., Dong Z.M., Hu J.Y.* Exposure assessment of PCDD/Fs for the population living in the vincity of municipal waste incinerator: Additional exposure via local vegetable consumption. Environmental Pollution, 2017, 224, 532-540.
53) Zhang Z.B., Hu Y., Guo J.L., Yu T., Sun L.B., Xiao X., Zhu D.S.*, Nakanishi T., Hiromori Y., Li J.Y., Fan, X.L., Wan Y., Cheng S.Y., Li J., Guo X., Hu J.Y.* Fluorene-9-bisphenol is anti-oetrogenic and may cause adverse pregnancy outcomes in mice. Nature Communications, 2017, 14585.

52) Ho K.L., Yuen K.K., Yau M. S., Murphy M.B.*, Wan Y., Fong B.M.W.*, Tam S., Giesy J.P., Leung K.S.Y., Lam M.H.W. Glucuronide and sulfate conjugates of tetrabromobisphenol A (TBBPA): Chemical synthesis and correlation between their urinary levels and plasma TBBPA content in voluntary human donors. Environmental International, 2017, 98, 46-53.

51) Zhao F.R., Wan Y., Zhao H.Q., Hu W.X., Mu D., Webster T., Hu J.Y.* Levels of blood organophosphorus flame retardants and association with changes in human sphingolipid homeostasis. Environmental Science & Technology, 2016, 50, 8896-8903.
50) Zheng G.M., Wan Y.*, Hu J.Y. Intrinsic Clearance of Xenobiotic Chemicals by Liver Microsomes: Assessment of Trophic Magnification Potentials. Environmental Science & Technology, 2016, 50, 6343-6353.

49) Wang B.L., Wan Y.*, Zheng G.M., Hu J.Y. Evaluating a Tap Water Contamination Incident Attributed to Oil Contamination by Nontargeted Screening Strategies. Environmental Science & Technology, 2016, 50, 2956-2963.

48) Wang B.L., Wan Y.*, Gao Y.X., Zheng G.M., Yang M., Wu S., Hu J.Y. Occurrences and Behaviors of Naphthenic Acids in a Petroleum Refinery Wastewater Treatment Plant. Environmental Science & Technology, 2015, 49, 5796-5804.

47) Gao S.X., Wan Y.*, Zheng G.M., Luo K., Kannan K., Giesy J.P., Lam M.H.W., Hu J.Y. Organobromine comound profiling in human adipose: Assessment of sources of bromophenol. Environmental Pollution, 2015, 204, 81-89.

46) Ho K.L., Yau M.S., Murphy M.B.*, Wan Y., Fong B.M.W.*, Tam S., Giesy J.P., Leung K.S.Y., Lam M.H.W. Urinary bromophenol glucuronide and sulfate conjugates: Potential human exposure molecular markers for polybrominated diphenyl ethers. Chemosphere, 2015, 133, 6-12.

45) Zhang H., Zhang Z.B., Nakanishi T., Wan Y., Hiromori Y., Nagase H., Hu J.Y.* Structure-dependent activity of phthalate esters and phthalate monoesters binding to human constitutive androstane receptor. Chemical Research in Toxicology, 2015, 28, 1196-1204.

44) Zhang Z., Peng H., Wan Y., Hu J.Y.* Isomer-Specific Trophic Transfer of Perfluorocarboxylic Acids in the Marine Food Web of Liaodong Bay, North China. Environmental Science & Technology, 2015, 49, 1453-1461.

43) Zhang Q.Q., Jia A., Wan Y., Liu H., Wang K.P., Peng H., Dong Z.M., Hu J.Y.* Occurrences of Three Classes of Antibiotics in a Natural River Basin: Association with Antibiotic-Resistant Escherichia coli. Environmental Science & Technology, 2014, 48, 14317-14325.

42) Peng H., Wan Y., Zhang K., Sun J.X., Hu J.Y.* Trophic transfer of Dechloranes in the Marine Food Web of Liaodong Bay, North China. Environmental Science & Technology, 2014, 48, 5458-5466.

41) Wan Y., Wang B.L., Khim J.S.*, Hong S.J., Shim W.J., Hu J.Y.* Naphthenic Acids in Coastal Sediments after the Hebei Spirit Oil Spill: A Potential Indicator for Oil Contamination. Environmental Science & Technology, 2014, 48, 4153-4162.

40) Wang B.L.,Wan Y.*, Gao Y.X., Yang M., Hu J.Y. Determination and characterization of oxy-naphthenic acids in oilfiled wastewater. Environmental Science & Technology, 2013, 47, 9545-9554.

39) Wan Y., Zhang K., Dong Z.M., Hu J.Y.* Distribution is a major factor affecting bioaccumulation of decabrominated diphenyl ether: Chinese sturgeon (Acpenser sinensis) as an example. Environmental Science & Technology, 2013, 47, 2279-2286.

38) Wan Y., Jia A., Zhu Z., Hu J.Y.* Transformation of tetracycline during chloramination: Kinetics, products and pathways. Chemosphere, 2013, 90, 1427-1434.

37) Ho K.L., Murphy M.B, Wan Y., Fong B.M.W., Tam S., Giesy J.P., Leung K.S.Y., Lam M.H.W.* Synthesis and characterization of bromophenol glucuronide and sulfate conjugates for their direct LC-MS/MS quantification in human urine as potential exposure markers for polybrominated diphenyl ethers. Analytical Chemistry, 2012, 84, 9881-9888.

36) Peng H., Zhang K., Wan Y., Hu J.Y.* Tissue distribution, maternal transfer, and age-related accumulation of dechloranes in Chinese strugeon. Environmental Science & Technology, 2012, 46, 9907-9913.

35) Wu X.Q., Jiang J.Q., Wan Y., Hu J.Y.* Cyanobacteria blooms produce tetratogenic retinoic acids, Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(24), 9477-9482.

34) Liu F.Y., Wiseman S.*, Wan Y., Doering J.A., Hecker M., Lam M.H.W., Giesy J.P. Multi-species comparison of the mechanism of biotransformation of MeO-BDEs to OH-BDEs in fish. Aquatic Toxicology, 2012, 114, 182-188.

33) Ma F.J., Wan Y., Yuan G.X., Meng L.P., Dong Z.M., Hu J.Y.* Occurrence and source of nitrosamines and secondary amines in groundwater and its adjacent Jialu River basin, China. Environmental Science & Technology, 2012, 46, 3236-3243.

32) Zhang K., Wan Y.*, Jones P.D., Wiseman S., Giesy J.P., Hu J.Y.* Occurrence and Fates of Hydroxylated Polybrominated Diphenyl Ethers in Marine Seidmens in Relation to Trophodynamics. Environmental Science & Technology, 2012, 46, 2148-2155.

31) Jia A., Wan Y., Xiao Y., Hu J.Y.* Occurrence and fate of Quinolone and Fluoroquinolone Antibiotics in a Municipal Sewage Treatment Plant. Water Research, 2012, 46, 387-394.

30) Chang H., Wan Y., Hu J.Y.* Occurrence of Androgens and Progestogens in Sewage Treatment Plants and Receiving River Waters: Comparison to estrogens. Water Research, 2011, 45, 732-740.

29) Wiseman S., Wan Y., Chang H., Zhang X.W., Hecker M., Jones P.D., Giesy J.P.* Polybrominated diphenyl ethers and their hydroxylated/methoxylated analogs: Environmental sources, metabolic relationships, and relative toxicities. Marine Pollution Bulletin, 2011, 63, 179-188.

28) Bradley P.W., Wan Y., Jones P.D., Wiseman S., Chang H., Lam M.H.W., Long D.T., Giesy J.P. Polybrominated Diphenyl Ethers and Methoxylated Analogues in Sediment Cores from Two Inland Lakes in Michigan. Environmental Toxicology and Chemistry, 2011, 30, 1236-1242.

27) Nail J.E., Khim J.S.*, Wang T.Y.*, Wan Y., Luo W., Hu W.Y., Jiao W.T., Park J.S., Ryu J.S., Hong S.J., Jones P.D., Lu Y.L., Giesy J.P. Source and distribution of polychlorinated-dibenzo-p-dioxins and -dibenzofurans in soil and sediment from the Yellow Sea region of China and Korea. Environmental Pollution, 2011, 159, 907-917.

26) Cohen-Barnhouse A.M., Zwiernik M.J., Link J.E., Fitzgerald S.D., Kennedy S.W., Hervé J.C., Giesy J.P., Wiseman S., Yang Y., Jones P.D., Wan Y., Collins B., Newsted J.L., Kay D., Bursian S.J.* Sensitivity of Japanese Quail (Coturnix japonica), Common Pheasant (Phasianus colchicus) and White Leghorn Chicken (Gallus gallus domesticus) Embryos to In Ovo Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), 2,3,4,7,8- Pentachlorodibenzofuran (PeCDF) and 2,3,7,8-Tetrachlorodibenzofuran (TCDF). Toxicological Sciences, 2011, 119, 93-103.

25) Wan Y., Liu F.Y., Wiseman S*., Zhang X.W.*, Chang H., Hecker M., Jones P.D., Lam M.H.W., Giesy J.P. Interconversion of Hydroxylated and Methoxylated Polybrominated Diphenyl Ethers in Japanese Medaka. Environmental Science & Technology, 2010, 44, 8729-8735.

24) Wan Y., Jones P.D., Wiseman S., Chang H., Chorney D., Kannan K., Zhang K., Hu J.Y., Khim J.S., Tanabe S., Lam M.H.W., Giesy J.P.* Contribution of Anthropogenic and Naturally Occurring Organobromine Compounds to Bromine Mass in Marine Organisms. Environmental Science & Technology, 2010, 44, 6068-6073.

23) Wan Y., Choi K.*, Kim S., Ji K., Chang H., Wiseman S., Jones P.D., Khim J., Park S., Park J., Giesy J.P. Hydroxylated polybrominated diphenyl ethers and bisphenol A in pregnant women and their matching fetuses: placental transfer and potential risks. Environmental Science & Technology, 2010, 44, 5233–5239.

22) Wan Y.*, Jones, P.D., Holem, R.R., Khim, J.S., Chang, H., Kay, D.P., Roark, S.A., Newsted, J.L., Patterson, W.P., Giesy, J.P. Bioaccuulation of polychlorinated dibenzo-p-dioxins, dibenzofurans, and co-planar polychlorinated biphenyls in fishes from the Tittabawassee and Saginaw Rivers (Michigan, USA), Science of the Total Environment, 2010, 408, 2394-2401.

21) Chang H., Wan Y.*, Naile J., Zhang X.W., Wiseman S., Hecker M., Lam M.H.W., Giesy J.P., Jones P.D. Simultaneous quantification of multiple classes of phenolic compounds in blood plasma by liquid chromatography-electrospray tandem mass spectrometry. Journal of Chromatography A, 2010, 1217, 506-513.

20) Zhang K., Wan Y., Giesy J.P., Lam M.H.W., Wiseman S., Jones J.D., Hu J.Y.* Tissue Concentrations of Polybrominated compounds in Chinese Sturgeon (Acipenser sinensis): Origin, Hepatic Sequestration, and Maternal Transfer. Environmental Science & Technology 2010, 44, 5781-5786.

19) Peng H., Wei Q.W., Wan Y., Giesy J.P., Li L.X., Hu J.Y.* Tissue distribution and maternal transfer of poly- and perfluorinated compounds in Chinese sturgeon (Acipenser sinensis): Implications for reproductive risk. Environmental Science & Technology, 2010, 44 (5), 1868-1874.

18) Zhang K., Wan Y., An L.H., Hu J.Y.* Trophodynamics of polybrominated diphenyl ethers (PBDEs) and methoxylated PBDEs in a marine foodweb, Environmental Toxicology and Chemistry, 2010, 29, 2792-2799.

17) Hervé J.C., Crump D., Jones S.P., Mundy L.J., Giesy J.P., Zwiernik M.J., Bursian S.J., Jones P.J., Wiseman S.B., Wan Y., Kennedy S.W.* Cytochrome P4501A induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and two chlorinated dibenzofurans in primary hepatocyte cultures of three avian species, Toxicological Sciences, 2010, 113(2), 380-391.

16) Yang Y.F., Wiseman S.B.*, Hervé J.C., Farmahin R., Cohen-Barnhouse A., Wan Y., Jones, P.D., Newsted J.L., Kay D.P., Kennedy S.W., Zwiernik M.J., Bursian S.J., Giesy, J.P. Effects OF In Ovo Exposure of white leghorn chicken, common pheasant, and Japanese quail to 2,3,7,8-tetrachlorodibenzo-p-dioxin and two chlorinated dibenzofurans on CYP1A induction. Environmental Toxicology and Chemistry, 2010, 29 (7), 1490-1502.

15) Wan Y.*, Wiseman S., Chang H., Zhang X.W., Jones P.D., Hecker M., Kannan K., Tanabe S., Hu J.Y., Lam M.H.W., Giesy J.P. Origin of hydroxylated brominated diphenyl ethers: natural compounds or man-made flame retardants? Environmental Science & Technology 2009, 43, 7536-7542.

14) Chang H., Wan Y., Hu J.Y.* Determination and source apportionment of five classes of steroid hormones in urban rivers. Environmental Science & Technology 43, 7691-7698, 2009.

13) Hu J.Y.*, Zhang Z.B., Wei Q.W., Zhen H.J., Zhao Y.B., Peng H., Wan Y., Giesy J.P., Li L.X., Zhang B. Malformations of the endangered Chinese sturgeon, Acipenser sinensis, and its causal agent, Proceedings of the National Academy of Sciences of the United States of America, 2009, 106(23), 9339-9344.

12) Wan Y., Hu J.Y.*, Zhang K., An L.H. Trophodynamics of polybrominated diphenyl ethers in the marine food web of Bohai Bay, north China, Environmental Science & Technology 2008, 42, 1078-1083.

11) Wan Y., Wei Q.W.*, Hu J.Y.*, Jin X.H., Zhen H.J., Liu J.Y. Levels, tissue distribution and age-related accumulation of synthetic musk fragrances in Chinese sturgeon (Acipenser Sinensis): comparison to organochlorines, Environmental Science & Technology, 2007, 41, 424-430.

10) Wan Y., Jin X.H., Hu J.Y.*, Jin F., An W., An L.H., Zhen H.J. Trophic dilution of polycyclic aromatic hydrocarbons (PAHs) in a marine food web from Bohai Bay, North China, Environmental Science & Technology, 2007, 41, 3109-3114.

9) Wan Y., Hu J.Y.*, An W., Zhang Z.B., An L.H., Hattori T., Itoh M., Masunaga S. Congener-specific tissue distribution and hepatic sequestration of PCDD/Fs in wild herring gulls from Bohai Bay, north China: comparison to coplanar PCBs. Environmental Science & Technology, 2006, 40, 1462-1468.

8) An W., Hu J.Y.*, Wan Y., An L.H., Zhang Z.B. Deriving site-specific 2,2-bis (chlorophenyl)-1,1-dichloroethylene (p,p`-DDE) quality criteria of water and sediment for protection of common tern populations in Bohai Bay, north China. Environmental Science & Technology, 2006, 40, 2511-2516.

7) Hu J.Y.*, Zhen H.J., Wan Y., Gao J.M., An W., An L.H., Jin F., Jin X.H. Trophic magnification of triphenyltin in marine food web: Comparison to tributyltin, Environmental Science & Technology, 2005, 40, 3142-3147.

6) Hu J.Y.*, Jin F., Wan Y., Yang M., An L.H., An W., Tao S. Trophodynamic behavior of 4-nonylphenol and nonylphenol polyethoxylate in a marine aquatic food web: comparison to DDTs, Environmental Science & Technology, 2005, 39, 4801-4807.

5) Wan Y., Hu J.Y.*, Yang M., An L.H., An W., Hattori T., Itoh M. Tao S. Characterization of trophic transfer for PCDD/Fs and coplanar PCBs in the marine food web of Bohai Bay, North China, Environmental Science & Technology, 2005, 39, 2417-2425.

4) Wan Y., Hu J.Y., Liu J.L., An W. Tao S. Fate of DDT-related compounds in Bohai Bay and its adjacent Haihe Basin, north China, Marine Pollution Bulletin, 2005, 50, 439-445.

3) Wan Y., Hu J.Y.*, An L.H., An W., Yang M., Itoh M., Hattori T., Tao S. Determination of trophic relationships within a Bohai Bay food web using δ15N and δ13C analysis, Chinese Science Bulletin, 2005, 50, 1021-1025.

2) Hu J.Y.*, Wan Y., Shao B., Jin X.H., An W., Jin F., Yang M., Wang X.J. Sugisaki M. Occurrence of trace organic contaminants in bohai bay and its adjacent nanpaiwu rRiver, north China, Marine Chemistry, 2005, 95, 1-13.

1) Gao J.M., Hu J.Y.*, Wan Y., An W., An L., Zheng Z.G. Butyltin compounds distribution in the coastal waters of Bohai Bay, People’s Republic of China, Bull. Environ. Contam. Toxicol. 2004, 72, 945-953.